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But was not until 1963 that Mechoulam and Shyo discovered the chemical structure of the CBD and enlightening the comprehension of the nature of the cannabinoids 3. At the next year 1964 Gaoni and Mechoulam finally elucidated the chemical structure of the main psychoactive compound of cannabis the THC matching the starting point of the modern pharmacology of cannabis 4. found in cannabis that belong to a class of molecules called cannabinoids. Of these compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied.